If you work in women’s health, you already know the golden rule: just when you think you’ve got a guideline memorized, the ink dries, and the updates drop. Medicine moves fast, and this month is no exception. Today, we are diving straight into the fresh-off-the-press October 2026 ACOG Practice Advisory on Premature Ovarian Insufficiency. Now, if you’re thinking, 'Wait, didn’t ACOG just reaffirm their POI guidance last year in 2025?'- you aren't crazy! They did. But clinical evidence doesn't wait around. ACOG has officially updated its stance to align directly with international consensus from ESHRE-the European Society of Human Reproduction and Embryology. So, what actually changed? How are we shifting our diagnostic thresholds, workups, and long-term hormone replacement strategies for these patients? We're covering all of it-the new shifts, the clinical pearls, and what you need to change in your practice starting today. Let’s get into it.
1. ACOG PA POI October 2026
2. ACOG Committee Opinion No. 605, Primary Ovarian Insufficiency in Adolescents and Young Women; July 2014.