August 21 2026 This Week in Cardiology

Mechanical CPR devices, the dangers of AF performance measures, two scholarly articles on CLOSURE and CHAMPION, and a little ESC preview are the topics John Mandrola, MD, discusses in this week's podcast. 

This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I Mechanical Compression Devices for OHCA

·       Mechanical CPR Device Use Cardiac Arrest Survival

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272

·       PARAMEDIC Trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext

·       CIRC Trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext

·       LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037

·       Cochrane Review of Mechanical vs Manual Chest Compressions for Cardiac Arrest  https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/

II ACC AF Performance Measures

·       2026 AHA/ACC Clinical Performance for Patients With AF https://www.jacc.org/doi/10.1016/j.jacc.2026.05.032#sec-3

III Two Critical Appraisals of the recent LAAC trials

·       Reappraising CHAMPION-AF 10.1016/j.hrthm.2026.07.048 External Link

·       CHAMPION and CLOSURE: Reconciling Contrast Results https://doi.org/10.1093/eurheartj/ehag608

ESC Early Preview

·       CMR Guide trial https://pmc.ncbi.nlm.nih.gov/articles/PMC6931571/

·       SINGLE AF Trial 10.1016/j.hroo.2025.12.008 External Link

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