People often think of weight loss drugs like GLP-1 and related agonists (e.g., Wegovy and Mounjaro) as “medications”--which they are, but they work because they mimic our own natural gut hormones to lower blood sugar, slow digestion, blunt appetite, and ultimately reduce weight. In that way, they’re weight health hormone replacement therapies much like estrogen and progesterone are sex hormone replacement therapies, says this week’s guest best-selling dietitian Ashley Koff, RD. We dig into weight-health hormones (GLP-1, GIP, PYY, CCK) that regulate appetite and metabolism, why digestion and hydration have to be optimized before nutrition even enters the picture, and how GLP-1 medications and hormone replacement therapy can work together in perimenopause and menopause. Plus: Ashley's own story of Everesting Mount Rainier at 52.

Ashley Koff, RD, is the USA Today bestselling author of Your Best Shot (HarperOne). With more than 25 years as a practitioner and educator, she's helped redefine the conversation from weight loss to weight health — a science-based framework focused on metabolic function and hormonal regulation. She's been named one of CNN's Top 100 Health Makers and "Hollywood's Leading Dietitian" by InStyle. You can learn more about her and her work at her practice, The Better Nutrition Program.

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