After over 15 years of full-time coaching with people from all walks of life to overcome all kinds of challenges that the nafs presents - in their professional, personal and spiritual lives - I can safely say, the answer is a resounding... "YES!"
Clients who had life-long patterns of self-sabotage, or seemingly irreconcilable marital issues - completely dissolved them. Forever. All thanks to spontaneously and permanently dropping ego-patterns. (In fact, you can check out a few of their testimonials on the page linked below).
It turns out that there are a handful of specific teachings, methods, insights and techniques that work for everyone and that make a HUGE difference in the 'battle' against the ego.