Prof Ramez N Eskander from UC San Diego Moores Cancer Center in California, Dr Bradley J Monk from Florida Cancer Specialists & Research Institute in West Palm Beach and Dr Kathleen N Moore from the Fred and Pamela Buffett Cancer Center in Omaha, Nebraska, review the treatment landscape of antibody-drug conjugate–directed therapy for gynecologic cancers and review recently presented clinical findings from the SGO 2026 Annual Meeting on Women’s Cancer.