Can bacteria-free, sterile faecal filtrate match conventional faecal microbiota transplantation for recurrent C difficile infection? Dina Kao (University of Alberta) unpacks a landmark multicentre trial that tested this hypothesis, and we discuss what it tells us about the role of living organisms in the therapeutic effects of microbiota-based therapies. Cli ... Show More
Feb 2026
Aleksander Krag on the utility of PEth for subclassifying individuals at risk of steatotic liver disease
Steatotic liver disease labels hinge on alcohol intake, but self-report is often inaccurate. In this episode, Aleksander Krag (Odense University Hospital) discusses a large Danish study using phosphatidylethanol (PEth), a direct blood biomarker of recent drinking, showing substan ... Show More
20m 20s
Nov 2025
Premysl Bercik on a double-blind crossover trial of gluten and wheat in IBS
Do wheat or gluten trigger IBS symptoms? We spoke to Premysl Bercik about a randomised, double-blind, sham-controlled crossover trial that challenged adults with IBS—who reported benefit from a gluten-free diet—with wheat, gluten, or a gluten-free sham to test symptom and behavio ... Show More
16m 21s
Sep 2025
Crohn's Strictures: New Guidelines and Future Directions
Dr. Refky Nicola speaks with Dr. Bari Dane, Associate Professor of Radiology at NYU, about the new SAR consensus recommendations for defining small bowel Crohn's disease strictures on CT and MR enterography. They explore updated imaging criteria, the challenges of distinguishing ... Show More
11m 44s
Aug 2022
158. Scoping Out for Dysplasia - An Approach to Barrett’s Esophagus
Send us Fan MailIn this episode, we review the clinical presentation, screening guidelines, diagnosis and management of Barrett's Esophagus - one of the risk factors for developing Esophageal Adenocarcinoma. In our medicine minute, we discuss a landmark trial that transitioned tr ... Show More
16m 13s
Nov 2022
Talk Evidence - Diabetes data, colonoscopies, and researchers behaving badly
In this month's Talk Evidence, Helen Macdonald, The BMJ's research integrity editor, is joined again by Juan Franco, editor in chief of BMJ EBM, and Joe Ross, US research editor.
They're straying beyond the pages of The BMJ, and discussing an NEJM paper about colonoscopy for co ... Show More
46m 15s
Oct 2023
Wanda Cui on measuring ovarian toxicity
<p>Dr. Wanda Cui (Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia) discusses her Review on measuring ovarian toxicity in clinical trials.<br/><br/>Read the full article:<br/><a href='https://www.thelancet.com/journals/lanonc/article/PIIS1470-20 ... Show More
10m 37s
Nov 2023
Low carb and cancer screening
<p>Each episode of Talk Evidence we take a dive into an issue or paper which is in the news, with a little help from some knowledgeable guests to help us to understand what it all means for clinical care, policy, or research. </p>
<p> </p>
<p>In this episode:</p>
<p>Helen Macdona ... Show More
33m 22s