A labor and delivery nurse who ran Senate healthcare policy now manages $1.7 trillion in federal health spending—and she runs her team like a startup.
Steph Carlton, Chief of Staff and Deputy Administrator at CMS, reveals the OKRs driving Medicare and Medicaid, why they're killing social determinants funding while building consumer health apps at scale, and ... Show More
Nov 17
How to Build This Generation's Big Pharma Company
<p>Drug discovery has doubled the flow of candidates, but approvals remain roughly flat. The constraint is development, not discovery. </p><p>In this episode, a16z General Partner, Jorge Conde talks with Formation Bio cofounder and CEO Ben Liu about building a modern pharma compa ... Show More
41m 4s
Nov 7
Dyno Therapeutics: Empowering Patients with Genetic Agency
<p>For the first time in human history, we can diagnose thousands of genetic diseases—often for under $1,000—but we still can't treat most of them. The problem isn't understanding what's broken; it's delivering the fix to the right cells.</p><p>Eric Kelsic, CEO of Dyno Therapeuti ... Show More
47m 28s
Sep 2024
Grand Challenges in Healthcare AI
<p>Vijay Pande, founding general partner, and Julie Yoo, general partner at a16z Bio + Health, come together to discuss the grand challenges facing healthcare AI today.</p><p>The talk through the implications of AI integration in healthcare workflows, AI as a potential catalyst f ... Show More
37m 40s
Sep 27
The Common Thread of All Technology: Monitoring the Situation, Ep.1
<p>Announcing our new show, Monitoring the Situation, hosted by a16z General Partners Erik Torenberg and Katherine Boyle, with guest Eddie Lazzarin, CTO of a16z crypto. </p><p>In this first episode, we ask how American Dynamism, consumer, games, and crypto all fit together, from ... Show More
1 h
Dec 2024
Fixing Education in America: What's Stopping Us?
<p>Over half of Americans live in childcare deserts, while 90% of brain development happens before the age of five. All the while, education and childcare remain among the most resistant sectors to technological change. Billions of dollars have been spent, but outcomes continue t ... Show More
38m 54s
Nov 2024
MI376: Why Do Great Companies Fail? The Innovator’s Dilemma w/ Shawn O’Malley
In today’s episode, Shawn O’Malley (@shawn_OMalley_) discusses why great companies fail, as outlined by Clayton Christensen in his timeless book, The Innovator’s Dilemma, which was first published in 1997. The Economist actually named it one of the six most important business boo ... Show More
45m 4s
Nov 2024
The Longevity Imperative: Redefining the Way We Age
<p>What if the biggest challenge of our time isn’t living longer, but living better? </p><p>In this episode, we’re tackling one of humanity’s greatest accomplishments—and perhaps its most overlooked challenge: longevity. As more people live past 100, our systems—healthcare, finan ... Show More
40m 30s
May 2025
Delivering More Connected Care Through AI: CVS Health's Josh Weiner
Josh Weiner, senior vice president of consumer engagement and analytics at CVS Health, is passionate about making health care more personalized, connected, preventative, and accessible. On today’s episode, Josh joins Sam and Shervin to explain how the integrated health care compa ... Show More
27m 22s
Sep 24
Software finally eats services - Aaron Levie
<p>Should the US put a price on H-1B visas, or would that block the flow of new talent? Are AI coding agents actually making teams way more productive, or is it just hype? And in the AI platform shift, will the big winners be incumbents or new AI-native startups?</p><p>Erik Toren ... Show More
59m 33s