Episode 455: ESMO 2025 Urothelial Cancer...

summaryThis detailed discussion covers the latest phase three trial results in kidney cancer, focusing on LITESPARK 011: Belzutifan and Levatnib combination versus Cabozantinib. Brian, Tom and Bob Motzer analyze efficacy, safety, and implications for treatment sequencing. 

This in-depth discussion explores the latest advancements in adjuvant kidney cancer treatment, focusing on the recent phase 3 trial results of Belzutifan combined with Pembrolizumab, mechanistic insights, biomarker development, and future research directions. 

The conversation revolves around the Sunrise 2 trial, a study investigating the efficacy of TAR-200 combined with cetrilimab versus traditional chemoradiotherapy in muscle-invasive bladder cancer. The discussion covers the study's design, patient population, results, and implicat ... Show More

<p>Today’s episode is focusing on bladder cancer - what you need to know about the pathology, presentation, diagnostic work-up, staging, treatment, and rarer upper GU tract presentations.</p> 

<p>We are doing a special episode this week to cover some of the key GU abstracts from ESMO 2024. We cover an update on the STAMPEDE prostate cancer trial, SUNNIFORECAST in non-clear cell renal cell carcinoma, SunRISe-4 in bladder cancer, and more.</p> 

<p>This is the first of a two part episode on prostate cancer. This episode will cover localized prostate cancer, including the diagnostic work-up, staging and treatment. </p> 

Hot off the press: The BOSS (Barrett’s Oesophagus Surveillance Versus Endoscopy at Need Study) randomised control study. Is surveillance really not affecting survival in oesophageal cancer patients? To put things into perspective, we asked Massimiliano Di Pietro, UEG Talks podcas ... Show More

<p class="p1">Chris Hughen sat down with Tom Jesson to take a deep dive into the lower limb neuro exam. We discuss the purpose of a neuro exam, screening and stewarding, the 3 P's of nerve function, diagnostic buckets, reassurance and education, sensory, strength and reflex testi ... Show More

<p class="" data-rte-preserve-empty="true" style="white-space:pre-wrap;">It’s time for another new series, this time focusing on Testicular Cancer. In this first episode, we lay the foundation for our future discussions and discuss the basics of Testicular Cancer.</p><p data-rte- ... Show More

<p class="" style="white-space:pre-wrap;">In this week’s episode, we discuss the management of stage II colon adenocarcinoma, which is defined by a lack of nodal involvement and invasion through the muscularis layer of the colon. If you have not done so already, be sure to check ... Show More

<p>This week, we round out our discussion on metastatic colorectal cancer, focusing on more targeted therapies for this disease. If you have not done so already, be sure to check out episode 107 for the first part of our metastatic colorectal cancer discussion.</p><p>Contents: </ ... Show More

Our guest is Dr. Kyle Richards, a urologic oncologist and Associate Professor in the Department of Urology at the University of Wisconsin. He talks with us about the basics around non-muscle invasive bladder cancer. Learn about common symptoms, diagnosis and treatment options to ... Show More

<p class="" style="white-space:pre-wrap;">This week, we kick off a new series focusing on diffuse large B-cell lymphoma. In this first episode, we discuss the basics that everyone needs to understand before diving into the management of this disease. </p><p class="" style="white- ... Show More