NEJM This Week — September 18, 2025

This week, we look at new research on potassium optimization in patients with defibrillators, reducing antihypertensive therapy in nursing homes, an mRNA influenza vaccine, and belzutifan for rare neuroendocrine tumors. We review long QT syndrome and present a case of abnormal be ... Show More

In this episode, we look at new trials on deferring arterial catheterization in shock, beta-blocker use after myocardial infarction, and a treatment for triple-negative breast cancer. We review acromegaly. A case describes a man with dyspnea, edema, and pacemaker lead displacemen ... Show More

In this episode, we discuss long-term outcomes after chest-wall irradiation for breast cancer, new treatments for psoriasis and obesity, and early results on a vaccine for Lassa fever. We review opioid deprescribing and a clinical case describes spiraling into a distant past. Per ... Show More

<p>This week’s episode will be focusing on Esophageal and Gastrosophageal Junction (GEJ) Cancer. We will go over important details on the risk factors, diagnosis, and treatment for both localized and metastatic esophageal cancer.</p><p><br/></p> 

<p>Ninja Nerds!</p><p>In this episode of the Ninja Nerd Podcast, Zach and Rob discuss <b>Colorectal Cancer</b>. This comprehensive discussion focuses on the clinical presentation, pathogenesis, and management of one of the most common malignancies encountered in clinical practice ... Show More

<p>Ninja Nerds!<br/>In this episode of the Ninja Nerd Podcast, Zach and Rob dive into the essential clinical and pathophysiologic features of urinary tract malignancies, beginning with renal cell carcinoma (RCC) and followed by urothelial carcinoma of the bladder.<br/><br/>We sta ... Show More

<p>Ninja Nerds!</p><p><br/>In this episode of the Ninja Nerd Podcast, Zach and Rob discuss two high-yield, board-relevant cases highlighting the diagnosis, staging, and treatment of esophageal adenocarcinoma and intestinal-type gastric adenocarcinoma.<br/><br/>We begin with a 56- ... Show More

In the September 2, 2025 JACC This Week, Editor-in-Chief Harlan M. Krumholz, MD, SM, FACC highlights the issue. Listen here for a summary of our latest content, including new research on cognitive dysfunction in adults with congenital heart disease, a review of calcific aortic va ... Show More

<p>Ninja Nerds,</p><p>Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we explore <b>Chronic Leukemias</b>, focusing on their pathogenesis, clinical features, and modern treatment strategies. We compare <b>Chronic Myeloid Leukemia (CML) and Chronic Lymphocyti ... Show More

<p>This week’s episode will be focusing on Gastric Adenocarcinoma. We will go over all the important details on risk factors, diagnostic work-up, staging and treatment for both local regional disease and metastatic disease with updates in 2025 since we last covered this topic in ... Show More

<p>Ninja Nerds,</p><p>Welcome to the Ninja Nerd Podcast with Zach and Rob! In this episode, we dive deep into <b>Acute Leukemias</b>, breaking down their pathophysiology, clinical presentation, and management. We explore the key differences between <b>Acute Myeloid Leukemia (AML) ... Show More

Heart failure with reduced ejection fraction (1:30), lower gastrointestinal bleeding (5:10), venous leg ulcers (7:10), nonopioid pharmacologic management of chronic pain (10:30), resuscitation in burns (15:20), and breast ductal carcinoma in situ (17:10). 

Tocotrienols, the superior forms of Vitamin E, provide powerful benefits that include lowering cholesterol, reducing inflammation, improving fatty liver and type 2 diabetes, and promoting bone health. Research has also suggested that tocotrienols may help fight against Crohn's Di ... Show More