NEJM This Week — September 11, 2025

This week, we look at new research on potassium optimization in patients with defibrillators, reducing antihypertensive therapy in nursing homes, an mRNA influenza vaccine, and belzutifan for rare neuroendocrine tumors. We review long QT syndrome and present a case of abnormal be ... Show More

In this episode, we look at new trials on deferring arterial catheterization in shock, beta-blocker use after myocardial infarction, and a treatment for triple-negative breast cancer. We review acromegaly. A case describes a man with dyspnea, edema, and pacemaker lead displacemen ... Show More

In this episode, we discuss long-term outcomes after chest-wall irradiation for breast cancer, new treatments for psoriasis and obesity, and early results on a vaccine for Lassa fever. We review opioid deprescribing and a clinical case describes spiraling into a distant past. Per ... Show More

<p>The medical system in Lebanon has faced significant challenges since 2019 due to a combination of economic, political, and security factors. The explosion of August 2020 and the last 10 days have posed significant challenges to the system. </p> <p>In this episode co-hosted wit ... Show More

Cognitive enhancers and Mini-Mental State Examination (1:40), primary care of adult cancer survivors (4:00), bupropion for depression in adolescents (8:50), acute and chronic prostatitis (10:50), antibiotics in uncomplicated but febrile urinary tract infections (14:10), and top 2 ... Show More

In this episode, Dr. Harlan Krumholz reviews the September 9, 2025 issue of JACC, covering key studies on artificial intelligence in cardiovascular research, the effects of tirzepatide in heart failure with preserved ejection fraction (HFpEF), and how social, racial, and genetic ... Show More

Intimate partner violence (1:40), top 20 research studies of 2024 for primary care physicians (5:20), treatments for carpal tunnel syndrome (11:20), benzgalantamine for Alzheimer disease (13:50), bright light therapy (17:50), assessment and management of patients at risk for suic ... Show More

Fatigue is a common symptom of multiple sclerosis, significantly impacting the quality of life of people living with the disease. In this episode, Dr. Anne-Laure Dubessy of Hôpital Pitié-Salpêtrière in Paris and Professor Iris-Katharina Penner of the University Hospital of Bern i ... Show More

Five articles from the August 2024 issue summarized in five minutes, with the addition of a brief editorial commentary. The 5-in-5 feature is designed to give readers an overview of articles that may pique their interest and encourage more detailed reading. It may also be used by ... Show More

Chronic cough is common. And from 10% to 70% of patients with chronic cough may have upper airway cough syndrome. So it is important that we get the diagnosis and management of this condition right. To find out more about this problem and what we can do about it, please do listen ... Show More

<p>This week’s episode will be focusing on Gastric Adenocarcinoma. We will go over all the important details on risk factors, diagnostic work-up, staging and treatment for both local regional disease and metastatic disease with updates in 2025 since we last covered this topic in ... Show More

In the September 2, 2025 JACC This Week, Editor-in-Chief Harlan M. Krumholz, MD, SM, FACC highlights the issue. Listen here for a summary of our latest content, including new research on cognitive dysfunction in adults with congenital heart disease, a review of calcific aortic va ... Show More

On this month's EM Quick Hits podcast: Stephen Freedman on pediatric bloody diarrhea, S-TEC and hemolytic uremic syndrome, Justin Morgenstern on the evidence for IM epinephrine in out of hospital cardiac arrest, Matthew McArther on recognition and ED management of dengue fever, A ... Show More