logo
episode-header-image
Sep 2025
26m 29s

ON CRISPR Episode 1: Beginnings

iHeartPodcasts and Kaleidoscope
About this episode

Earlier this year, when the world learned the news of baby KJ successfully undergoing the first personalized genetic treatment, it represented a milestone for researchers and patients. But behind this scientific feat there’s the story of the technology that made it possible, CRISPR, and one of the key pioneers behind it — Jennifer Doudna. 

Evan sits down with Walter Isaacson to understand how Doudna’s upbringing in Hilo, Hawaii influenced her trajectory as a gene editing scientist. And how the history of gene editing might have started with understanding DNA, but soon after, it became clear the real secret lay with its underrated sibling molecule, RNA.

See omnystudio.com/listener for privacy information.

Up next
Sep 2025
ON CRISPR Episode 2: The Discovery
Back in the 1990s, a young microbiologist in Alicante, Spain became obsessed with a strange pattern he observed in the genes of tiny organisms — a series of inexplicable clusters. And he wasn’t alone. All around the world, a network of scientists were growing curious as to what t ... Show More
30m 50s
Sep 2025
ON CRISPR Episode 3: Patent Wars
Jennifer Doudna thought she had won the race. She thought she had beaten out all scientific competitors when she and her co-author had shocked the world with their groundbreaking technology for gene editing. But turned out, the race had just gotten fiercer. Walter Isaacson sits d ... Show More
27m 19s
Oct 1
ON CRISPR Episode 4: Franken Monsters
As the gene editing field kept growing, so did the dangers. Back in 2018, Jennifer Doudna received an email from a Chinese scientist claiming that he had genetically edited two twin babies. The news reverberated across the world and made Doudna and her colleagues urgently conside ... Show More
36m 47s
Recommended Episodes
Jan 2025
Benjamin Franklin's Electric Mind
The dramatic story of an ingenious man who explained nature and created a country. 📕 Ingenious: A Biography of Benjamin Franklin, Scientist 📩 Check out our daily Substack and our weekly LinkedIn newsletter 
8m 49s
Jul 2024
The Franklin Guide (Free Preview)
Topics on the Franklin Guide to taking over the world include: How to convince someone of your viewpoint Why Franklin almost started a swimming school Franklin's love life Was Benjamin Franklin a shallow person? + much more! ----- To subscribe, visit takeoverpod.supercast.com If ... Show More
7m 43s
Jun 2024
168 Benjamin Franklin
📖 Episode Transcripts in Link Below ⬇️ Today, we will delve into the life and achievements of Benjamin Franklin, one of the most remarkable figures of the 18th century, known for his contributions to science, politics, and diplomacy. https://patreon.com/HistoryinSlowGerman?utm_m ... Show More
4m 40s
Mar 2021
From DaVinci to CRISPR
<p>Walter Isaacson’s latest exploration of the lives of creative geniuses focuses on Jennifer Doudna, the co-inventor of the revolutionary gene editing tool CRISPR. Alan explores with Isaacson his fascination with people who have changed the world, from Leonardo to Benjamin Frank ... Show More
46m 32s
Jun 2024
Benjamin Franklin | The Flame of Liberty | 2
<p>In the spring of 1775, Benjamin Franklin left London for America after years of fruitless attempts to ease tensions with the British government. By the time he arrived home in Philadelphia, American and British soldiers had fired the first shots of the Revolutionary War, and F ... Show More
38m 38s
Aug 2024
The Founding of the Smithsonian, Part Two: James Gives America a Fortune -- and a Mission
There's no way around it: James Smithson had a tough life. Yet his unhappiness may, in an indirect way, be the prime reason the Smithsonian Institute exists today. In part two of this special two-part episode, special guest Lizzie Peabody, the host of Sidedoor, delves into the st ... Show More
32m 37s
Apr 2025
How to Build Resilience (with Ben Walter from The Unshakeables)
In a special episode brought to you by Chase for Business, Dr. Laurie joins Ben Walter—CEO of Chase for Business and host of The Unshakeables podcast—to talk about resilience. Dr. Laurie and Ben explore the story of Benjamin Haugh, founder of All Nation Restoration in Austin, Tex ... Show More
35m 23s
Feb 2025
Ben Franklin: Secret Spy
Benjamin Franklin is known for his role as a Founding Father, inventor, and diplomat. But he had another role: spymaster. As the American colonies fought for independence against the British, Franklin traveled to Paris to help win French support. But as it turned out, he was ente ... Show More
41m 44s
Jul 2025
Success Decoded with Maz Hakim
Welcome to Success Decoded, the podcast where Maz Hakim explores the real stories behind global success across different industries. In episode one, Maz sits down with Piers Morgan as he shares the mindset, mistakes, and moments that shaped his journey.See omnystudio.com/listener ... Show More
31s
Dec 2023
Mobits Extra: How Norman Lear Changed Television
Starting in the early 1970s, Norman Lear changed the face of television, fusing comedy with social commentary. Lear died on December 5th at the great old age of 101. Mo revisits their 2015 conversation for CBS Sunday Morning.See omnystudio.com/listener for privacy information. 
16m 38s