Juana I of Castile (1479-1555) was the third child of Isabella of Castile and Ferdinand of Aragon. She's remembered now for being "Juana La Loca/Juana The Mad" but, in fact, that reputation was just part of a larger scheme that found her caught between her ambitious and terrible husband and her ambitious and terrible father.

References:

Sister Queens: The Noble, Tragic Lives of Katherine of Aragon and Juana, Queen of Castile by Julia Fox

Juana I: Legitimacy and Conflict in Sixteenth-Century Castile by Gillian B. Fleming

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Women Leaders, part 8: How Mad Was Juana...