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Nov 2024
1h 30m

Parmita Mishra — How to Think About Biol...

Jim O'Shaughnessy
About this episode

Parmita Mishra is a computational biologist and the founder & CEO of Precigenetics, a company aiming to become a rocket to precision medicine.

Parmita is deeply knowledgeable about cutting-edge biology, particularly epigenetics — how behavior and environment can affect gene function without altering genetic code. Her passion for advancing our understanding of diseases is inspiring (and contagious: OSV is an investor in Parmita’s company!)

In our conversation, Parmita and I discuss everything from the curious case of male baldness to how her parents have saved 50,000 lives. 

I hope you enjoy this conversation as much as I did. For the full transcript, highlights, and bucketloads of other goodies designed to make you go, “Hmm, that’s interesting!”, check out our Substack.

Important Links:

Show Notes:

  • Explaining epigenetics to a golden retriever
  • The curious case of male pattern baldness
  • How to think about biology: start from first principles & beware binary thinking
  • The lens you look through determines what you see
  • The problem of data collection in biology
  • Why the FDA needs to change its approach
  • Why we still don’t understand the human brain
  • Garry Tan’s advice: “Get an idea. Get a co-founder.”
  • What’s been surprising about foundership?
  • Failure is a ladder
  • Obsession & how Parmita’s parents have saved 50,000 lives
  • The most surprising things about America
  • Parmita as World Empress

Books Mentioned:

  • What is Life?; by Erwin Schrodinger
  • I should have loved biology; by James Somers
  • Gödel, Escher, Bach: An Eternal Golden Braid; by Douglas Hofstadter
  • The Hypomanic Edge: The Link Between (A Little) Craziness and (A Lot of) Success in America; by John D. Gartner
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