Molecular Testing Pearls
In Part 4 of our Heme Path series, we thoroughly examine the details of molecular testing and how it relates to hematologic and oncologic malignancies
I. Molecular Testing Basics
A. Provides a means of assessing patient’s genotypes, specifically at smaller changes in the genetic information
B. How is it performed?
1. Polymerase ch ... Show More
Sep 17
Episode 139: Follicular Lymphoma Series, Pt 4 - Relapsed/Refractory Management (Cellular therapy options)
<p class="" data-rte-preserve-empty="true" style="white-space:pre-wrap;"><strong>This week, we continue talking about relapsed/refractory follicular lymphoma, this time focusing on cellular therapy options, namely bispecific agents and CAR T therapy. If you have not done so, we h ... Show More
36m 11s
Sep 10
Episode 138: Follicular Lymphoma Series, Pt 3 - Relapsed/Refractory Management (non-cellular therapy options)
<p class="" data-rte-preserve-empty="true" style="white-space:pre-wrap;"><strong>This week, we shift our focus to talking about relapsed/refractory follicular lymphoma. In this episode, we will specifically discuss treatment options other than cellular therapy, which will be an u ... Show More
29m 51s
Jun 2025
Episode 137: Follicular Lymphoma Series, Pt 2. - Front-line Management
<p class="" data-rte-preserve-empty="true" style="white-space:pre-wrap;">This week, we continue our conversation on follicular lymphoma, this time focusing on front line therapy. We discuss how we approach localized and diffuse disease and the data behind why we do what we do. </ ... Show More
30m 11s
Mar 2025
Decoding Risk: Understanding Polygenic Risk Scores in Modern Medicine. Demystifying Genetics with Erica Spaeth
<p>This episode dives into polygenic risk testing, exploring how genetic data can inform healthcare strategies. We discuss the complexities of communicating risk, the role of polygenic scores in identifying disease susceptibility, and the evolving landscape of personalized medici ... Show More
49m 41s
Oct 3
Genetics: Gene Expression
In this episode, we explore key topics in genetics, including how sex-linked and autosomal traits are inherited. We'll break down inheritance patterns using real-world examples, like X-linked recessive diseases, and walk through Punnett square problems to show how these traits ar ... Show More
52m 43s
Jul 2024
Genetic Testing for Sports Performance
In this episode, I discuss genetic testing for sports and athletic performance. I describe the history of sports genomics and the search for genes that determine strength, endurance, and other performance markers. I explain how to interpret genetic test results, including how man ... Show More
1h 43m
Aug 2024
Episode 147: Genetic Mutation and Repair
Here we survey of the causes and consequences of genetic mutation, including a discussion of mechanisms of endogenous and induced mutations, rates of mutation, types of single nucleotide mutations, and the phenotypic effects of mutation. We also discuss various mechanisms for det ... Show More
1h 13m
Apr 2024
Switzerland, AI and Liquid Biopsies
AI and predictive modeling to understand an individual’s immune system function and predict treatment response are still in very early stages. We dream about precision medicine and getting every answer we can for ourselves when we get sick. However, if we look at genomics, only a ... Show More
36m 51s
Sep 24
Episode 65. Circulating Tumor DNA in DLBCL with Dr. Ash Alizadeh and Dr. David Russler-Germain
In this episode of Blood Cancer Talks, hosts Eddie, Ashwin, and Raj welcome two distinguished experts to explore the cutting-edge field of circulating tumor DNA (ctDNA) in B-cell lymphomas. Dr. David Russler-Germain, a lymphoma clinician from Siteman Cancer Centre at Washington U ... Show More
53m 8s
May 2025
Behaviors That Alter Your Genes to Improve Your Health & Performance | Dr. Melissa Ilardo
My guest is Dr. Melissa Ilardo, Ph.D., professor of biomedical informatics at the University of Utah. We discuss the interplay between genes and behaviors, including how certain behaviors can improve resilience by changing gene and organ function, as well as natural selection eve ... Show More
1h 54m
Nov 2024
Cancer Cells Gone Wild: Real Biology Exposed
In this episode, Dr. Jessica Steier and Dr. Sarah Scheinman discuss the complexities of cancer with Dr. Joe Zundell, a cancer biologist. They explore the definition of cancer, its prevalence, and the hallmarks that characterize cancer cells. The conversation delves into the mecha ... Show More
59m 38s