A couple of weeks ago, Charlie Marsh and the folks at Astral made another big splash with a major release of uv called "uv: Unified Python packaging" which has many far reaching features. We had to have Charlie on the show to give us the inside look into this development. Let's get to it.
Jan 13
#534: diskcache: Your secret Python perf weapon
Your cloud SSD is sitting there, bored, and it would like a job. Today we’re putting it to work with DiskCache, a simple, practical cache built on SQLite that can speed things up without spinning up Redis or extra services. Once you start to see what it can do, a universe of poss ... Show More
1h 14m
Jan 5
#533: Web Frameworks in Prod by Their Creators
Today on Talk Python, the creators behind FastAPI, Flask, Django, Quart, and Litestar get practical about running apps based on their framework in production. Deployment patterns, async gotchas, servers, scaling, and the stuff you only learn at 2 a.m. when the pager goes off. For ... Show More
1h 1m
Dec 29
#532: 2025 Python Year in Review
Python in 2025 is in a delightfully refreshing place: the GIL's days are numbered, packaging is getting sharper tools, and the type checkers are multiplying like gremlins snacking after midnight. On this episode, we have an amazing panel to give us a range of perspectives on what ... Show More
1h 18m
Aug 2025
911: The Future of Python Notebooks is Here, with Marimo’s Dr. Akshay Agrawal
Reproducibility, Python notebooks, and data science communities: Software developer Akshay Agrawal speaks to Jon Krohn about Marimo, the next-generation computational notebook for Python, how he built and fostered a thriving community around the product, and what makes this noteb ... Show More
58m 20s
Jun 2018
Python at Microsoft (Interview)
We talked with Steve Dower and Dan Taylor at Microsoft Build 2018 about the history of Python at Microsoft, the origination of IronPython, Python Tools for Visual Studio, flying under the radar to add support Python, fighting from within to support open source, and more.
37m 51s
Aug 2025
Live from Big Sky Dev Con: Code Debates, Content Insights, and What's Next for Web Development
Live from Big Sky Dev Con, Robbie is joined by Aaron Francis, Ken Wheeler, and Typecraft to discuss HTML and CSS programming status, React’s future, app security failures, NPM’s weak spots, content creation hooks, survival tech fantasies, and balancing big tech ambitions with fam ... Show More
50m 55s
Sep 2024
Late Night Linux – Episode 299
Learning undergraduate level signal processing for free, a few more uses for KDE Connect, analysing audio for HiFi setups, deep inspection of Python objects, viewing HTTP archives, and more on the problem with micropayments. Discoveries Signal Processing Course KDE Connect Fritur ... Show More
23m 12s
Nov 2016
Python, Django, and Channels (Interview)
Django core contributor Andrew Godwin joins the show to tell us all about Python and Django. If you've ever wondered why people love Python, what Django's virtues are as a web framework, or how Django Channels measure up to Phoenix's Channels and Rails' Action Cable, this is the ... Show More
1h 15m