Two downsides of PFA including autonomic tone and hemolysis, a bad surrogate in AF care, and controversies in defining cardiac risk are the topics John Mandrola, MD, covers in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I.PFA and Its (lack of) Effect on Autonomic Tone

Pulsed Field Ablation for AF: Are US Electrophysiologists Too Easily Impressed?

https://www.medscape.com/viewarticle/pulsed-field-ablation-af-are-us-electrophysiologists-too-2024a1000d2v

Autonomic Tone Paper https://doi.org/10.1016/j.jacep.2024.05.005
ADVENT https://www.nejm.org/doi/full/10.1056/NEJMoa2307291

II. Second PFA Study JACC-EP—on Hemolysis

Hemolysis study https://doi.org/10.1016/j.jacep.2024.05.001
MANIFEST 17K https://www.nature.com/articles/s41591-024-03114-3
Defaye Editorial https://www.jacc.org/doi/abs/10.1016/j.jacep.2024.06.007

III. A Self-serving Surrogate Marker: Diagnosis to Ablation Time.

CAPLA Study https://jamanetwork.com/journals/jama/fullarticle/2800186
CAPLA Substudy https://doi.org/10.1016/j.jacep.2024.05.031
EHJ RCT Early vs Late https://doi.org/10.1093/eurheartj/ehad247
LOOP; Diederichsen and colleagues 10.1016/j.jacc.2019.09.050
Groningen and Maastricht Group study https://heart.bmj.com/content/109/3/186

IV. Future Cardiac Risk

Diao and colleagues Study of AHA PREVENT Risk Equations https://jamanetwork.com/journals/jama/fullarticle/2821624
JAMA Editorial https://jamanetwork.com/journals/jama/fullarticle/2821542
Another JAMA Editorial https://jamanetwork.com/journals/jama/fullarticle/2821628

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