There have been drastic changes made in the regulation of opioids for medical treatment in the past few decades. However, with advent of fentanyl and carfentanil addiction, overdose-related death continues to increase. In this episode, our guests discuss continued regulation of opioids, use of naloxone and when it may not counteract an overdose, the case for limiting the use of opiates in elderly populations who have existing co-morbidities, and how the use of opioids in certain populations continues to be appropriate.