Today is a long-awaited show with none other than Bryan Johnson, an entrepreneur, venture capitalist, author, and professional rejuvenation athlete on a mission to discover the next evolution of humankind. While Bryan is well known in the longevity space, I’ve been a fan of his work for years because of his neuroscience background.

Bryan started a company called Kernel, which makes devices that monitor and record brain activity. Kernel uses what I would call the most comprehensive way of looking at the human brain ever. He is the founder of OS Fund and Braintree, and he spearheads Project Blueprint, an anti-aging experiment where he’s spent multiple years and millions of dollars developing an algorithm to live longer.

In today’s wide-ranging talk, we discuss the future of optimizing our brains with AI—delving into all things biohacking and longevity while exploring complicated questions like… Can you die of loneliness? And… Are your critics making you old?

Plus, we talk testosterone—an often triggering topic, but an essential conversation. Bryan shares his perspective on why he would rather be respected by people in the 25th century than understood now. Stick around for his surprising takes on olive oil, body hair, and saunas.

(00:59) Biohacking The Brain

(05:34) Are Your Critics Making You Old?

(12:52) What Makes Bryan Tick

(20:09) The Longevity-Loneliness Connection

(28:27) Accounting For Bio Individuality in Health Protocols

(39:09) Does Having a Partner Help You Live Longer?

(47:59) Olive Oil vs. Saturated Fats

(54:39) Talking Testosterone

(01:07:52) Expanding Consciousness with Psychedelics

(01:12:06) Questions from the Live Audience

Sponsor: Try Qualia NAD+ with an extra 15% off with code Dave15.

Resources: