Firearm suicide takes the lives of thousands of US youths annually, and the economic burden of youth violence is high, especially from male firearm homicides. JAMA Pediatrics Editor in Chief Dimitri Christakis, MD, and JAMA Pediatrics Associate Editor Alison A. Galbraith, MD, discuss the burden of gun violence and prevention of firearm-related injuries with JAMA Network Open Editor Frederick P. Rivara, MD, MPH, of the Seattle Children’s Hospital. Related Content: