The Anglican-run al Ahli hospital in northern Gaza was bombed on Tuesday evening, claiming 500 lives, according to the Palestinian health ministry. Both sides in the Israel-Hamas war have blamed the other.
It comes as US President Joe Biden lands in Israel to discuss the conflict. He appeared to back the Israeli military account that the blast was not caused by them.
On the Sky News Daily, host Belle Donati hears from General Sir Simon Mayall, former senior adviser for the Middle East at the Ministry of Defence, to understand the military outlook on the ground in Israel and the wider region.
Belle also speaks to Lishay Lavi whose husband Omri Miran was kidnapped from kibbutz Nahal Oz and taken to the Gaza Strip on 7 October.
Plus, our Middle East correspondent Ali Bunkall updates us on the al Ahli hospital bombing and Biden's visit.
Senior Producer: Annie Joyce
Producer: Soila Apparicio
Interviews Producer: Melissa Tutesigensi
Editor: Paul Stanworth