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Oct 2023

33m 51s

Trial of the Week: CRASH-3

About this episode

Trial of the Week: CRASH-3

Special Guest: Ruben Santiago, PharmD, BCPS, BCCCP

Ruben Santiago joins me to discuss the landmark article “Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with

acute traumatic brain injury (CRASH-3)” published in Lancet.

We review the history of TXA use in trauma, what the CRASH-3 study ultimately found, how does this compare to previous studies, what are guideline recommendations, applying this info in the viscoelastic testing era, and much more.

Reference list: https://pharmacytodose.files.wordpress.com/2023/10/crash3-tow-references.pdf

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