logo
episode-header-image
Apr 2023
45m 27s

#392 Live! Opioid and Xylazine Withdrawa...

The Curbsiders Internal Medicine Podcast
About this episode
Dominate opioid and xylazine (aka tranq) withdrawal in the hospital with expert insights from Dr. Joseph D’Orazio (@dorazepam) recorded LIVE! at Pennsylvania Hospital Grand Rounds in Philadephia, PA. Xylazine, an alpha-2 adrenergic agonist,  has emerged as a frequent contaminant in the opioid supply with a distinct withdrawal syndrome. You’ll learn to manage this common withdrawal syndrome while also addressing acute pain complaints and opioid withdrawal.  

Sorry, no CME for this episode, but check out CME for past episodes at curbsiders.vcuhealth.org.

Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME

Show Segments

  • Intro
  • Xylazine basics
  • Management of xylazine withdrawal
  • Opioid withdrawal and acute pain
  • Outpatient considerations for xylazine
  • Audience questions
  • Outro

Credits

  • Writer and Producer: Matthew Watto MD, FACP
  • Infographic and Cover Art: Matthew Watto MD, FACP
  • Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP   
  • Reviewer: Emi Okamoto MD
  • Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP
  • Technical Production: PodPaste
  • Guest: Joseph D’Orazio MD

Full transcript available HERE 


Up next
Jul 7
490: Update! Anticoagulation for Venous Thromboembolism with Dr. Tara Lech, PharmD
Master the latest approaches for treating venous thromboembolism with expert tips on direct oral anticoagulant (DOAC) selection, dosing, and duration. Learn how to tailor anticoagulation for special populations, handle treatment failures, and navigate long-distance travel risks. ... Show More
1h 24m
Jun 30
#489 Live from SHM #Converge2025 Rheumatology for the Hospitalist
Take the ache out of those joint aches! Learn about inpatient diagnosis and management of crystalline arthropathies as well as a brief conversation about those rheumatology NOS cases. We’re joined by Dr. Kimberly Trotter, MD (University of Chicago). Claim CME for this episode at ... Show More
47m 14s
Jun 23
#488 DIGEST: Cytisinicline for smoking cessation, partner treatment for BV, combination therapy with statins and ezetimibe, and exercise and survival in colon cancer
Join us as we review recent practice-changing articles on the effect of combination statin and ezetimibe in reducing myalgias, male partner treatment for BV, semaglutide for MASH/liver fibrosis, exercise and cancer risk, and cytisinicline for smoking cessation. Fill your brain ho ... Show More
1h 3m
Recommended Episodes
Sep 2023
S2 Ep12: #23 Opioid Overdose Treatment and Prevention with Dr. Alex Walley
Prevent opioid overdoses in your community! We discuss opioid overdose prevention and treatment so you can counsel patients who use substances on ways to decrease their risk of overdose. We discuss optimal ways to respond to hospital overdoses, ideal doses of naloxone, and how to ... Show More
1 h
Jun 2023
Episode 854: Tranq (xylazine) with Heroin
Contributor: Aaron Lessen, MD Educational Pearls: What is Tranq? Tranq is the street name for xylazine, a sedative drug typically used in veterinary medicine. Xylazine has recently emerged as a recreational drug, often mixed with heroin or fentanyl.  The mechanism of action of xy ... Show More
2m 56s
Sep 2020
96 Treatment of Opioid Withdrawal with Buprenorphine
Join Dan McCollum and EM clinical pharmacist RJ LaCoursiere as they discuss the use of buprenorphine for the treatment of Opioid Use Disorder. Who should be considered for treatment with Medication-Assisted Treatment (MAT)? Why should it be avoided if the patient isn't in acute w ... Show More
21m 4s
Oct 2022
Are Psychedelics The Solution To The Opioid Crisis? with Deborah Mash
This episode is brought to you by Cozy Earth, InisdeTracker, and Rupa Health. If you or a loved one struggle with addiction, this is an episode you’re going to want to listen to. Many of our current pharmaceuticals stem from compounds discovered in plant medicines. And many benef ... Show More
1h 20m
Jun 2024
Opioid Use Disorder in the ED - An Interview with Corey Hazekamp, MD, MS
In this episode, Sam Ashoo, MD and T.R. Eckler, MD interview Corey Hazekamp, MD, MS, one of authors of the June 2024 Emergency Medicine Practice article, Managing Emergency Department Patients With Opioid Use Disorder Current State of Opioid EpidemicOverview of overdose deaths an ... Show More
44m 10s
May 2023
S2 Episode 3: HIV and Opioid Use Disorder: Screening Tools, Chronic Pain Management, and Access to Care in the Outpatient Setting
Drs Michael S. Saag and Ellen F. Eaton discuss HIV and opioid use disorder, including opioid agonists for chronic pain management, tools for reducing mortality, and management in the outpatient setting. Relevant disclosures can be found with the episode show notes on Medscape (ht ... Show More
25m 34s
May 2024
Episode 903: Treating Precipitated Opioid Withdrawal
Contributor: Aaron Lessen MD Educational Pearls: Opioid overdoses that are reversed with naloxone (Narcan), a mu-opioid antagonist, can precipitate acute withdrawal in some patients Treatment of opioid use disorder with buprenorphine can also precipitate withdrawal Opioid withdra ... Show More
2m 47s
Jan 2024
#326: Ozempic and Other Semaglutide Medications
Semaglutide, which is sold under the brand names Ozempic, Wegovy and Rybelsus, has become increasingly popular and is a medication you are likely to encounter in the clinical setting and when reviewing your patient’s medical histories. In this article, you’ll learn the key things ... Show More
17m 37s
Apr 2019
Opioids and Cancer Pain: Patients’ Needs and Access Challenges
Dr. Pennell talks with Dr. Ray Page about efforts to address the opioid crisis impact onthe care of patients, and what role oncologists can play on this issue.   Hello, and welcome to the ASCO Journal of Oncology Practice podcast. This is Dr. Nate Pennell, medical oncologist at t ... Show More
14m 5s
Oct 2017
27 - The First Opiate Epidemic
The United States is in the midst of an epidemic of addiction and overdose deaths due to opiate painkillers. Its causes are varied, but there’s no question that physicians share a large part of the blame. Little discussed is that this is actually the second time this has happened ... Show More
28m 3s
Listen to millions of songs and podcasts on Anghami