This episode outlines an approach to systemic juvenile idiopathic arthritis (JIA). Listeners will learn the classification criteria, clinical features, and complications of systemic JIA as well as the role of a general pediatrician in its management. This podcast was developed by Dr. Rebecca Quilty, a pediatrics resident at Memorial University of Newfoundland in collaboration with Dr. Ronald Laxer, a pediatric rheumatologist at the University of Toronto.