logo
episode-header-image
May 2023
30m 37s

49. Penicillin Allergy 2: Delabel Harder

Infectious Disease: Insights of Two Specialists
About this episode

Welcome to the party pal! The penicillin allergy assessment and delabelling party, that is. Callum takes Jame through the latest evidence base in antibiotic allergy in general, and beta lactam allergy assessment and management in particular. 

Links: 
PENFAST Score paper: 
Trubiano JA et al. Development and Validation of a Penicillin Allergy Clinical Decision Rule. doi: 10.1001/jamainternmed.2020.0403.

Sulfonamide allergy paper here (couldn't find anything published more recently): 
Urbancic KF et al. Taking the challenge: A protocolized approach to optimize Pneumocystis pneumonia prophylaxis in renal transplant recipients. doi:10.1111/ajt.14498

Dutch beta lactam allergy guidelines: 
https://swab.nl/en/exec/file/download/192

And finally...
Norvell MR et al. Cefazolin vs. second-line antibiotics for surgical site infection prevention after total joint arthroplasty among patients with a beta-lactam allergy. https://doi.org/10.1093/ofid/ofad224

Yippee Ki-Yay, my delabellers, we'll see you in a fortnight. 

Support the show

Questions, comments, suggestions to idiotspodcasting@gmail.com or Tweet us @IDiots_pod

Prep notes for completed episodes can be found here: https://1drv.ms/u/s!AsaWoPQ9qJLShugmB2EOm8FMePNBtA?e=IKApb5

If you are enjoying the podcast please leave a review on your preferred podcast app!

Feel like giving back? Donations of caffeine gratefully received!
https://www.buymeacoffee.com/idiotspod

Up next
Jul 7
113. The yeasts: Cryptococcus part 1, overview and diagnosis
In this episode we are uncovering the most cryptic of cocci, Cryptococcus!Alyssa and Callum are joined by Jeremy Day to learn all things neo(formans) about this important pathogenic yeast. In this episode we discuss the epidemiology, clinical presentations and diagnosis of Crypto ... Show More
44m 31s
Jun 23
112. An Exacerbating Expansion on Endocarditis - part 2
In this episode, Callum and Jame discuss the latest evidence base for endocarditis assessment & management, focusing on the ESC 2023 guidance. Echocardiography indicationsSurgeryAntimicrobial treatmentsASTAND MORE…in part 1 because this is was 2-parter.Show notes for this episode ... Show More
42m 50s
Jun 11
111. An Exasperating Expansion on Endocarditis, Part 1
In this episode, Callum and Jame discuss the latest evidence base for endocarditis assessment & management, focusing on the ESC 2023 guidance. Epidemiology! Prophylaxis! How to take a blood culture! A long and complicated comparison of the Duke-ISCVID and Duke-ESC criteria that d ... Show More
38m 36s
Recommended Episodes
Jun 2019
4: Is it safe to administer cefazolin in penicillin-allergic patients?
We investigate the claim that an alternative antibiotic to cephalosporins (e.g., cefazolin) should be selected for penicillin-allergic patients in the perioperative setting.  Claim 1. Alternative antibiotics may be as efficacious in preventing surgical site infections Claim 2. Ce ... Show More
54m 31s
Feb 2022
Nut allergies: causes, consequences and emerging treatments
Nut allergies are one of the most common types of food allergy seen in children and adults. Caused when the body’s immune system overreacts to proteins found in nuts or peanuts, it can lead to a range of symptoms from mild reactions to severe anaphylaxis that is life-threatening. ... Show More
12m 45s
Jun 2023
Why Allergies Are On The Rise with Professor Theresa MacPhail #374
Pollen counts are rising and more of us are experiencing hay fever symptoms than ever before. From airborne allergens to the food on our plates or the chemicals and plants that touch our skin, around 40% of the global population has some form of allergic disease. By 2030, today’s ... Show More
2h 33m
Aug 2020
155: Oral Allergies + Cross Reactivity: How It Can Trigger Itchiness + Hives w/ Rakhi Roy, MS, RD, LDN
Have you ever hard of oral allergy syndrome? No? Well, you're not alone. My guest today will share some surprising facts about oral allergy syndrome, as well as cross-reactivity within allergies. My guest today, Rakhi Roy Chowdhury, holds a Master’s in Dietetics & Nutrition ... Show More
35m 2s
Mar 2022
REBOOT #151 Anaphylaxis
Recognize common presentations of anaphylaxis and stop under-treating this deadly allergic reaction with tips from Dr. Olajumoke Fadugba, Assistant Professor of Medicine, University of Pennsylvania! We review the basic pathophysiology and the standard criteria for diagnosing anap ... Show More
40m 49s
Aug 2022
REBOOT #284 An Antibiotics Primer, with @IDdocAdi
On this Curbsiders classic, we discuss antibiotic classes, common uses, the pathophysiology behind antibiotic mechanisms, and much more with infectious disease expert, Dr. Adi Shah MBBS (@IDdocAdi)! This antibiotics primer will break down the (cell) walls of antibiotic knowledge. ... Show More
57m 32s
Sep 2022
Cephalexin (Keflex) Pharmacology Podcast
On this podcast episode, I discuss cephalexin pharmacology, adverse effects, drug interactions, and much more! Penicillin allergies and cross-reactivity are common questions with regard to the use of cephalexin and I discuss this briefly in the podcast episode. Cephalexin is a fi ... Show More
12m 24s
Jun 2024
Episode 72: Nefecon for IgAN, The NefIgArd part B trial
The Filtrate:Joel TopfJosh WaitzmanWith Special Guest:Brad Rovin (@BradRovin) Chief of nephrology at The Ohio State University Wexner Medical Center, one of the authors of the Nefigard trial. Koyal Jain (@koyaljainMD) Program director of the GN Fellowship at University of North C ... Show More
1h 32m