The Filtrate:
Joel Topf
Swapnil Hiremath
Jordy Cohen
With Special Guest:
Laurie Tomlinson. @Roxytonin Nephrologist at University Hospitals Sussex and research hero of Jordy.
Editor:
Priya Yenebere
Show Notes:
STOP-ACE in pubmed: Renin-Angiotensin System Inhibition in Advanced Chronic Kidney Disease
STOP-ACE Summary in NephJC
Prior data showing preservation of renal function by stopping ACEi: The impact of stopping inhibitors of the renin-angiotensin system in patients with advanced chronic kidney disease
Efficacy and Safety of Benazepril for Advanced Chronic Renal Insufficiency: NEJM
Dr. Tomlinson’s article on creatinine changes in RASi from 2017: Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study NephJC | PubMed
Accuracy of eGFR at low GFR: A new equation to estimate glomerular filtration rate
Strong opinions, loosely held.
“Permissive AKI” with treatment of heart failure. Editorial by Chirag Parish and Steven Coca
The rational for NICE avoiding RASi in black patients: Hypertension and ethnic group
AASK trial showing superiority of RASi in African Americans. JAMA
ALLHAT post-hoc analysis of outcomes by self-reported race. JAMA | PubMed
Sophisticated Swedish observational study that Swap loved. Stopping Renin-Angiotensin System Inhibitors in Patients with Advanced CKD and Risk of Adverse Outcomes: A Nationwide Study
Target Trials in Nephrology Dr Edouard Fu grand rounds at Ottawa Nephrology, YouTube
Target Trial EmulationA Framework for Causal Inference From Observational Data by Miguel Hernán in JAMA
Tubular Secretions
Jordy: Third season of His Dark Materials on HBO
Swap: Movies by Wes Anderson on Disney Plus
Laurie: The Book, “Nearly All the Men in Lagos are Mad”
Jordy: How Medicine Works and When It Doesn't: Learning Who to Trust to Get and Stay Healthy | Amazon
Joel EO | NYT Review