Carolyn Bertozzi and Degrading Drugs for...

Out-of-Pocket is a healthcare education company founded by Nikhil Krishnan that helps people understand how healthcare works and how to navigate it in practice. In this episode, a16z investing partner Jay Rughani and Nikhil discuss why health insurance is losing its role as the d ... Show More

Cofounders Jeremy Wohlwend and Gabriele Corso join the a16z podcast to discuss the launch of Boltz, a public benefit company building AI infrastructure for molecular biology. The conversation explains how breakthroughs following AlphaFold moved the field beyond protein structure ... Show More

In this episode, a16z GP Julie Yoo sits down with Peter McCanna, CEO of Baylor Scott & White Health, to break down how one of America's largest health systems is transforming from a supply-driven "walled castle" to a customer-centric ecosystem, and how it's achieving a 10% operat ... Show More

In this episode:00:48 A new way to grow a tricky parasite in the labToxoplasma gondii, the parasite that causes the zoonotic disease toxoplasmosis, has a complex, multi-stage life cycle. Some of these stages will only grow in the intestines of cats, making it difficult to study. ... Show More

<p>Dr Tracy Anthony is a world-class scientist, Professor of Nutritional Sciences at Rutgers University, and expert on cellular responses to nutrition and exercise. She uses animal models to explore mechanisms of proteostasis. This lesser-known proteostasis network is directly ti ... Show More

Prions are biological anomalies – self-replicating, not-alive little particles that can misfold into an unstoppable juggernaut of fatal disease. Prions don't contain genes, and yet they make more of themselves. That has forced scientists to rethink the "central dogma" of molecula ... Show More

In recent years, there has been a surge of interest in the potential negative health effects of lectins. What are lectins? They’re a type of protein found in many plant foods such as legumes, wholegrains and some fruits and vegetables. If you take YouTube clips and popular diet b ... Show More

Proteomes, the sequences of protein within the DNA of every living thing, are notoriously difficult to model. The usual chemical methods can take months, but a new computational model using the ability of artificial intelligence to learn the complex sequences is able to predict s ... Show More

What do proteins do? Heck, an easier question to answer would be 'what don't they do?" No, seriously... I think they do, like, everything. Follow us on Twitter @SciShowTangents, where we’ll tweet out topics for upcoming episodes and you can ask the science couch questions! While ... Show More

In this episode:00:45 Why losing the Y chromosome makes bladder cancer more aggressiveLoss of the Y chromosome in bladder cancer cells is associated with increased severity of disease, but the reasons behind this have been unclear. Now researchers show that the loss of this chrom ... Show More

Although vaccines will go a long way to reducing the number of cases of Covid, there’s still a need for other approaches. One of these could be an engineered biomolecule, designed by virologists Anne Moscona and Matteo Porotto, that blocks SARS-CoV-2 precisely at the moment it tr ... Show More