Recognize common presentations of anaphylaxis and stop under-treating this deadly allergic reaction with tips from Dr. Olajumoke Fadugba, Assistant Professor of Medicine, University of Pennsylvania! We review the basic pathophysiology and the standard criteria for diagnosing anaphylaxis, treatment basics, the primary importance of epinephrine, and the utility of adjunctive therapies. Also included are great tips on counseling patients about auto-injectable epinephrine, and a reminder not to panic…even when you inject your own thumb?! Original show notes here.

Credits

Producer, infographic, and cover art: Emi Okamoto MD
Hosts: Matthew Watto MD, FACP; Stuart Brigham MD, Emi Okamoto MD
Editor: Matthew Watto MD, FACP
Guest: Olajumoke Fadugba MD
Special thanks to Sarah Phoebe Roberts MPH for booking!

Show Segments

Intro and disclaimer
Guest one-liner, book recommendation, advice to fellows and trainees
Case of anaphylaxis with mucocutaneous and GI symptoms
Anaphylaxis (IgE mediated mast cell action) vs anaphylactoid (non-IgE mediated mast cell activation; e.g. contrast allergy, vancomycin)
Vancomycin and non-IgE mediated reactions
Common presentations of anaphylaxis and the three diagnostic criteria
Biphasic reactions and predicting severity
Counseling patients on the use of epinephrine
Stuart’s thumb question
Adjuvant medications: antihistamines and corticosteroids
Are there any contraindications to epinephrine use?
Use of tryptase levels when the diagnosis of anaphylaxis is uncertain
Outro

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REBOOT #151 Anaphylaxis