About this episode
Mar 23
518: Cardiology Meets Longevity
Metabolic Health, Advanced Lipidology, and Preventing ASCVDLevel up your primary prevention game. Learn when ApoB, Lp(a), and CAC actually change management, how to spot cardiometabolic risk before diabetes declares itself, and how to make smarter lipid decisions beyond the stand ... Show More
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#517 DIGEST: Weight regain after weight loss medications, GLP1/GIP comparisons, valacyclovir for Alzheimer’s, and nudges to encourage deprescribing
Join us as we review and appraise recent practice-changing articles. In this episode, we cover the latest in GLP-1s and GIP agonists for CVD, Type 2 Diabetes, and Obesity, valacyclovir to treat Alzheimer’s, weight regain patterns after medication-induced weight loss, and a deep d ... Show More
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REBOOT: #481 Prediabetes and Diabetes Prevention with Dr. Scott Isaacs
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Oct 2020
18: Is mixing in lidocaine effective for preventing burning with propofol?
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I discuss Pyridostigmine Pharmacology in this podcast episode in addition to adverse effects, drug interactions, and much more! Pyridostigmine is an acetylcholinesterase inhibitor that can be used for myasthenia gravis or orthostasis. Pyridostigmine can blunt the effect of neurom ... Show More
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#326: Ozempic and Other Semaglutide Medications
Semaglutide, which is sold under the brand names Ozempic, Wegovy and Rybelsus, has become increasingly popular and is a medication you are likely to encounter in the clinical setting and when reviewing your patient’s medical histories. In this article, you’ll learn the key things ... Show More
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4: Is it safe to administer cefazolin in penicillin-allergic patients?
<p>We investigate the claim that an alternative antibiotic to cephalosporins (e.g., cefazolin) should be selected for penicillin-allergic patients in the perioperative setting. </p> <p>Claim 1. Alternative antibiotics may be as efficacious in preventing surgical site infections</ ... Show More
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On this episode, I discuss isotretinoin pharmacology, side effects, drug interactions, and much more. The iPLEDGE program is in place to ensure that pregnant patients do not receive this medication. I discuss this in more detail on this episode. Sun sensitivity is an important ad ... Show More
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Joel Rosh - Pediatric IBD Treatment Beyond Anti-TNFs
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9: Is it safe to peripherally administer norepinephrine?
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Pharmacotherapy for Anxiety and Depression
Special guest Marshall E. Cates, PharmD, BCPP, FASHP, FCCP, FALSHP, Professor of Pharmacy Practice from the McWhorter School of Pharmacy at Samford University joins us to talk about pharmacotherapy for anxiety and depression.Listen in as we discuss pharmacotherapy for managing ge ... Show More
31m 22s
May 2019
3: Does morphine cause more nausea than hydromorphone?
<p>We investigate the claim that morphine causes more nausea than hydromorphone. </p> <p>My guest is Dr. Daniel Saddawi-Konefka, program director of the Anesthesia Residency Program at Massachusetts General Hospital.</p> <p class="p1">Full show notes available at <a href= "applew ... Show More
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Apr 2023
Pyridoxine Pharmacology
On this episode, I discuss pyridoxine pharmacology, adverse effects, and important clinical uses. Pyridoxine is most well known for its potential to reduce the likelihood of isoniazid-induced neuropathy. Another common indication of pyridoxine is its use for nausea and vomiting a ... Show More
12m 20s
Recognize common presentations of anaphylaxis and stop under-treating this deadly allergic reaction with tips from Dr. Olajumoke Fadugba, Assistant Professor of Medicine, University of Pennsylvania! We review the basic pathophysiology and the standard criteria for diagnosing anaphylaxis, treatment basics, the primary importance of epinephrine, and the utility of adjunctive therapies. Also included are great tips on counseling patients about auto-injectable epinephrine, and a reminder not to panic…even when you inject your own thumb?! Original show notes
here.
Credits
- Producer, infographic, and cover art: Emi Okamoto MD
- Hosts: Matthew Watto MD, FACP; Stuart Brigham MD, Emi Okamoto MD
- Editor: Matthew Watto MD, FACP
- Guest: Olajumoke Fadugba MD
- Special thanks to Sarah Phoebe Roberts MPH for booking!
Show Segments
- Intro and disclaimer
- Guest one-liner, book recommendation, advice to fellows and trainees
- Case of anaphylaxis with mucocutaneous and GI symptoms
- Anaphylaxis (IgE mediated mast cell action) vs anaphylactoid (non-IgE mediated mast cell activation; e.g. contrast allergy, vancomycin)
- Vancomycin and non-IgE mediated reactions
- Common presentations of anaphylaxis and the three diagnostic criteria
- Biphasic reactions and predicting severity
- Counseling patients on the use of epinephrine
- Stuart’s thumb question
- Adjuvant medications: antihistamines and corticosteroids
- Are there any contraindications to epinephrine use?
- Use of tryptase levels when the diagnosis of anaphylaxis is uncertain
- Outro
Sponsor
<p class="p1"><span class="s1">In this episode, we discuss the mechanisms of burning with propofol infusion and explore the evidence behind strategies like mixing lidocaine with propofol.</span></p> <p class="p1"><span class="s1">Our guest today is Dr. Stu Forman, Professor of An ... Show More
<p>In this episode, Dr. <a href='https://twitter.com/PLLU'>Peter Lu</a> and Dr. <a href='https://twitter.com/JenniferLeeLee1'>Jennifer Lee</a> talk to Dr. <a href='https://www.linkedin.com/in/joel-rosh-797417139/'>Joel Rosh</a> about the latest advances in pharmacologic treatment ... Show More
<p class="p1">We investigate the claim that norepinephrine is not safe for peripheral administration.</p> <p class="p1">Our guests today are Dr. Katarina Ruscic and Dr. Jamie Sparling of the Critical Care Division of the Massachusetts General Hospital. </p> <p class="p1">Full sho ... Show More
