This special episode of Inside the Lab is a recording of the recent ASCP webinar "The Science of HER2-low Breast Cancer and Implications for the Pathology Team." This webinar is presented by Aysegul Sahin, MD, Professor of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX, USA; Ali Brown, MD, FASCP, American Society for Clinical Pathology, Chicago, IL, USA; and Erin Downs-Kelly, DO, Cleveland Clinic, Cleveland, OH, USA.