Sep 13

TWiV 1357: Furin, Naturally with Paul Bieinasz

Paul Bieniasz joins TWiV to discuss his lab's discovery that the coronavirus nuclease NSP15 cuts viral RNA into oligonucleotides that are reinserted elsewhere in the viral RNA, generating insertion mutations at a frequency above 10⁻³ per genome, including new furin cleavage sites ... Show More

1h 44m

Sep 12

TWiV 1356: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Daniel Griffin and Vincent Racaniello delve into dengue virus infections in Florida, recent human rabies infections in the US, proposed changes in biomedical funding including "converting" the Department of War into NIAID, the continuing controversy ... Show More

47m 17s

Sep 6

TWiV 1355: Four billion years of AI training data

TWiV reviews a landmark paper reporting the first generative design of complete viral genomes using AI, producing 16 viable bacteriophages that overcame antibiotic-resistant bacteria where natural phages could not, and a study suggesting that recombinant shingles vaccination redu ... Show More

1h 38m

Nov 2024

TWiEVO 108: A virus in every parasite

Nels and Vincent review the identification of a novel virus associated with the pathogen Plasmodium knowlsei and which is part part of a diverse and unclassified viral taxon. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): Apple Podcasts, RSS, email Become a patron of T ... Show More

1h 18m

Dec 2012

TWiP 48: A parasitic cloaking device

Hosts: Vincent Racaniello, Dickson Despommier, and Josef Sabo Vincent, Dickson, and Josef discuss tetraspanins on the surface of schistosomes as vaccine candidates and immune evasion proteins. Links for this episode: S. japonicum tetraspanin-2 as a vaccine target (PLoS NTP) Prote ... Show More

1h 7m

May 2022

'Where Are Vaccines for Little Kids?' and the Latest on Long COVID